Skip to main content
2025 AANS Annual Scientific Meeting Main banner

Cerebrovascular

The Impact of Troponin I Levels on Survival Status in Patients with Intracerebral Hemorrhage

    Presenting Author(s)

  • Wenxiong Song, MD

    Residents
    Beijing Tiantan Hospital, Capital Medical University

Introduction:

Introduction: Troponin I is a reliable marker of myocardial injury and is routinely measured in patients with atraumatic intracerebral hemorrhage (ICH). This study aims to investigate the potential impact of troponin I levels during hospitalization on post-discharge survival and functional status in patients with ICH.

Methods:

Methods:  We conducted an observational analysis of 460 hospitalized patients with atraumatic ICH, measuring the peak troponin I level during their hospital stay. Patients were stratified into three groups based on troponin I levels: ≤40 pg/mL, 41-50 pg/mL, and ≥50 pg/mL. Baseline characteristics were compared across groups. Survival status was evaluated at discharge and three months post-discharge using the modified Rankin Scale (mRS), categorizing outcomes as favorable (mRS 0-3) or unfavorable (mRS 4-6). The association between peak troponin I levels during hospitalization and survival status was analyzed using binary logistic regression.

Results:

Results:  Among the 460 patients, 413 had a peak troponin I level below 40 pg/mL, while 47 patients had elevated troponin I levels during hospitalization (41-50 pg/mL or ≥50 pg/mL). Specifically, 14 patients had mildly elevated levels (41-50 pg/mL), and 33 had severely elevated levels (≥50 pg/mL). High troponin I levels were significantly associated with poor survival status at three months post-discharge (mRS 4-6) (p=0.003, OR [95% CI]: 1.464-6.472). After adjusting for sex and age, elevated troponin I levels remained significantly associated with poor survival outcomes at three months (p < 0.001, OR [95% CI]: 1.656-7.367), reinforcing the association even after controlling for confounding factors.

Conclusion :

Conclusions:  Elevated troponin I levels are significantly associated with poor short-term survival outcomes in patients with atraumatic ICH. These findings suggest that heightened attention to cardiac events in this patient population during hospitalization may be clinically warranted.