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    Yingchao LIU, Ph.D ; M.D

    Head and director, Department of Neurosurgery
    Shandong Provincial Hospital of Shandong First Medical University

    Doctor Yingchao Liu received his PhD degree from the Department of neurosurgery, Huashan hospital, Fudan University, Shanghai, China, under the mentorship of professor Jianhong Zhu (Cheung Kong Scholar) in 2009. Now he is the head and chair of department of neurosurgery (more than 200 beds) of Shandong Provincial Hospital Affiliated to Shandong First Medical University at Jinan, China, where he completed specialized training in both micro-invasive neurosurgery and stereotactic radiosurgery. Beside the daily neurosurgical operation, Dr Liu is also actively engaged in the field of developing brain functional MRI since 2013, and has published more than 40 peer-reviewed research articles related to the glioma, brain metastasis and functional MRI. He has frequently given invited keynote lectures at international or domestic top-level meetings. As a neurosurgeon specialized in neuro-oncology, Dr Liu makes the heaviest use of diagnostic radiological imaging, especially functional magnetic resonance imaging and has done in-depth studies in water-exchange MRI imaging of glioma and its underlying mechanism in recent 5 years.
    To address temporal-spatial tumor proliferation heterogeneity issues of glioma in a noninvasive way, Dr Liu explored the feasibility of water-exchange MRI imaging modality with foundational publication of “Shutter-Speed DCE-MRI Analyses of Human Glioblastoma Multiforme (GBM) Data” in J Magn Reson Imaging（2020）. Based on this theoretical foundation, he jointly cooperate with professor Bai (Zhejiang University) to investigate the underlying mechanism of AQP4 for the contribution of water-exchange MRI and validated that AQP4 is associated with tumor cell water-exchange, and the AQP4 imaging heterogeneity could be a surrogate of tumor proliferation heterogeneity. The primary research results and conclusion has been accepted and in press with Nature biomedical engineering （2022）with full long article titled “Dynamic-contrast-enhanced magnetic resonance imaging for the detection of water exchange heterogeneity in glioma “. Until now, AQP4 molecular DCE-MRI been provided to over 600 patients at Shandong Provincial Hospital Affiliated to Shandong First Medical University, and the latest progress in AQP4 MRI is just accepted for publication in Theranostics with the title "In vivo spatiotemporal mapping of proliferation activityin gliomas via water-exchange MRI" as the cover story.

    Disclosure(s): No financial relationships to disclose

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