Consortium for Dural Arteriovenous Fistula Outcomes Research (CONDOR): Natural History of Dural Arteriovenous Fistulae

Introduction: The natural history of dural arteriovenous fistulas (dAVFs) varies based on lesional anatomical differences reflected in clinical and radiological findings. Risk stratification of to identify lesions prone to an aggressive natural history is imperative to guide safe and timely management of dAVFs.

Methods: Patients with aggressive outcomes were compared to the overall cohort from the international multi-center CONDOR consortium. Hypothesized variables were assessed by cause-specific and subdistribution hazard models on which cox and Fine-Gray multivariable models were built. Aggressive outcomes were defined as hemorrhage or non-hemorrhagic neurological deficits (NHND).

Results: Patients with aggressive outcomes were compared to the overall cohort from the international multi-center CONDOR consortium. Hypothesized variables were assessed by cause-specific and subdistribution hazard models on which cox and Fine-Gray multivariable models were built. Aggressive outcomes were defined as hemorrhage or non-hemorrhagic neurological deficits (NHND).

Conclusion : The present analysis of the cumulative data in the largest consortium on dAVFs aids in the risk stratification of dAVF patients and can be used as a guiding tool for timing of intervention and treatment strategy decision making.