Novel Wireless Peripheral Nerve Stimulator for Treatment of Peripheral Nerve Injury

Introduction: Peripheral nerve stimulation has proven efficacy in the treatment of nerve injury, pain management, and the creation of brain-computer interfaces. The rising median global age is driving demand for innovative methods to repair neurological damage which is notoriously unpredictable and slow to heal. Current peripheral nerve stimulation techniques often involve large, wired setups that may require multiple surgeries and can be both physically and psychologically detrimental due to visible implanted equipment. Together, these factors have produced a robust and growing market for nerve repair technology that may serve to benefit patients who need them the most. This study highlights a novel peripheral nerve stimulator that is small enough to be implanted in a rat and can deliver selective fascicle stimulation.

Methods: Our device is designed to be implanted into the sciatic nerve of anesthetized rats. Stimulation of the sciatic nerve with our electrode produces leg kicks, which were recorded with EMG.

Results: To our knowledge, a similar electrode design for peripheral nerve or muscle stimulation has not yet been done. Our results indicate that we can selectively stimulate different fascicles of the sciatic nerve, and we plan to improve the design by making it wirelessly powered. This device has demonstrated potential for therapeutic applications in larger animal models and eventually humans.

Conclusion : Our novel peripheral nerve stimulator shows promise for use in mammalian models without behavioral interference. Our long-term goal is to adapt and improve this technology for use in larger animals and humans, particularly for re-enervation of severed or injured nerves. This advancement could significantly enhance the therapeutic options available for nerve injuries and related conditions.