Ethnopharmacological Evaluation of Methanolic Extracts of Selected Medicinal Plants on Sensorimotor Functional Recovery Following a Traumatic Injury to Sciatic Nerve in Mouse Model

Introduction: Peripheral nerve injury (PNI) poses a serious threat to health and can lead to permanent
impairment or even death. Since there are inadequate safe and effective therapies accessible
against PNI, therefore it is necessary to investigate therapeutic approaches in order to restore
functional damage.

Methods: The current study aimed to investigate the impact of different plants
methanolic extracts on the restoration of muscular function following sciatic nerve damage in a
mouse model. Albino mice (n = 30, 8–10 weeks, 25–35 g in weight) were split into five equal
groups: Saline was given to the G1 (control group), and the following treatment groups received
their respective doses by gavage: G2 (O. europaea; 200 mg/kg BW), G3 (M. zapota; 400 mg/kg
BW), G4 (P. cineraria; 200 mg/kg BW), and G5 (C. zedoaria; 300 mg/kg BW).

Results: Behavioral analysis and histological examination revealed that the all treatment groups improved
sensorimotor functions was much faster (p < 0.05) as compared to control group. The treated
groups also showed significantly lower levels of oxidative stress and hyperglycemia.

Conclusion : In summary, although all treatment groups had encouraging outcomes, G5 outperformed the others and has the
potential to become a future medication option. However, more investigation is required to fully grasp the processes underlying the extract's improved functional restoration as well as its true therapeutic qualities.